Abstract: BACKGROUND ＆ AIM : To evaluate the changes of the serum TSGF (tumor specific growth factor) in patients with breast carcinoma(BC) and their familial members(FM).MATERIAL AND METHODS : The changes of serum TSGF in the 30 cases with BC and 30 FM were determined using spectrophotometry method. RESULTS: The serum level of TSGF in patients with BC(78.5±13.4),compared with normal subjects (NS)(48.8±6.2), were significantly increased(P<0.01).There also were statistical differences in serum level between FM(69.6±9.9) and the NS(P<0.01). CONCLUSION: It is suggested that changes of TSGF may serve as an indicator of diagnosis for BC and their susceptible individuals.

Key words: tumor specific growth factor, breast carcinoma, familial member